Spider-Gwen

In the alternate reality designated Earth-65, Gwen Stacy from Midtown High School is bitten by the radioactive spider and becomes a superhero going by the name of Spider-Woman. As Gwen Stacy, she is depicted as a drummer alongside her friends Mary Jane Watson, Betty Brant and Glory Grant, simply called the Mary Janes. Shortly after she begins fighting crime, one of her classmates, Peter Parker, attempts to exact revenge on those who bullied him in Midtown High School, becoming Earth-65's version of the Lizard. Gwen subdues him, but Peter dies towards the end of the battle due to the chemical he used. Spider-Woman is blamed for his death, causing an outcry for her arrest, led by J. Jonah Jameson. Her father, George Stacy, a NYPD police chief, begins a hunt for her along with Captain Frank Castle and Detective Jean DeWolff. While the Mary Janes are attempting to perform in a concert, an assassin is sent after Gwen Stacy's father, who is in the audience. As Spider-Woman, she successfully defeats the assassin. During the battle, Captain Stacy holds Spider-Woman at gun point, with Gwen Stacy taking off her mask to reveal who she is to her father. Shocked upon learning Spider-Woman's identity, he tells her to run before he changes his mind.[24]

In the comic series Spider-Gwen she battles various alternate versions of Spider-Man villains, such as Vulture, Kraven the Hunter and Harry Osborn as the Green Goblin.[16][25][26] Most recurringly, she deals with Matt Murdock as the lawyer and fixer for an imprisoned Kingpin of crime trying to corrupt Spider-Gwen into the lifestyle of crime along with Frank Castle hunting her down as a vigilante.[26] Despite her enemies, she also deals with heroic allies in Earth-65, such as Captain America (Samantha Wilson), Reed Richards and Peggy Carter, the leader of S.H.I.E.L.D.[26][27][11]

Gwen Stacy stars alongside Earth-616's Jessica Drew and Silk in a crossover comic book storyline entitled Spider-Women. The plot consists of her two companions being stuck within her world after battling with Super-Adaptoid when her dimensional wristwatch–that she obtained from "Spider-Verse"–was stolen.[28][29] They eventually discover that the Earth-65 version of Cindy Moon, leader of S.I.L.K., was the mastermind behind the stealing of the wristwatch. Earth-65's Cindy Moon revealed to Silk and Gwen Stacy that she stole the technology to take over the world. Earth-65's Cindy also revealed that one of her spiders was behind the bite that gave Gwen Stacy her powers. She proceeded in taking the latter's power away with the use of her technology and framed her Earth-616 counterpart of Silk.[30] Gwen, Jessica and Cindy later team up in defeating Earth-65's Cindy.[31]

The aftermath of the storyline deals with the effects of Gwen's loss of power and her need of isotopes to regain her power.[26] She agreed to become Matt Murdock's apprentice in exchange for unlimited isotopes as her father turned himself in to clear his daughter's name. Murdock and scientist Elsa Brock eventually found a way for Gwen to regain her powers and rid her friend Harry Osborn of the Lizard serum by combining the serum with the isotopes to form the Venom symbiote. She succeeds and ends up bonding to the symbiote, but Murdock allowed Rhino to beat George up in prison after she refused to turn Harry over to the Hand. This caused her to succumb to the symbiote's influence and she began brutally attacking the Hand and other criminals. After realizing how far she was taking it, she revealed her secret identity to the Parkers and her band mates. Ben encouraged Gwen to take revenge on Murdock and she almost succeeded in killing him, but decided against it after finding out that Murdock was testing to see if she could be corrupted by power as he was. The dimensional teleportation device Murdock stole from Gwen then sent her to Earth-617, a reality similar to Earth-616 prior to that Gwen's death. This universe's Gwen helps her with creating a portal back to her own dimension and makes her realize how lucky she is to have her dad still alive. Shortly after returning, she finally defeated Murdock, took full control over the symbiote, revealed her secret identity to the public, and was convicted for one year in a maximum security S.H.I.E.L.D. prison, despite an offer by Captain America to join a black ops team to reduce her sentences.[32] Later on she travels to Chicago to meet a boy name Samuel Hayden to become the Substitute of Spider-Man temporary for Peter Parkers absence.